RAT ANTI MOUSE CD102:FITC

GWB-818370

IgG2a

Phosphate buffered saline pH7. 4

COS cells transfected with murine ICAM-2

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response NK-cell mediated clearance lymphocyte recirculation and other cellular interactions important for immune response and surveillance. Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityExpressed in endothelial cells and leukocytes. High levels found in lung. Sequence similaritiesBelongs to the immunoglobulin superfamily. ICAM family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. 1. Fehervari Z. and Sakaguchi S. (2004) CD4+ Tregs and immune control. J. Clin. Invest. 114: 1209-1217. [1] \" Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. \" Tourvieille B. Gorman S. D. Field E. H. Hunkapiller T. Parnes J. R. Science 234:610-614(1986) [PubMed: 3094146] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [2] \" Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene. \" Littman D. R. Gettner S. N. Nature 325:453-455(1987) [PubMed: 3027575] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system. \" Parnes J. R. Hunkapiller T. Immunol. Rev. 100:109-127(1987) [PubMed: 3326818] [Abstract]Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain. [4] \" Structure of the mouse gene encoding CD4 and an unusual transcript in brain. \" Gorman S. D. Tourvieille B. Parnes J. R. Proc. Natl. Acad. Sci. U. S. A. 84:7644-7648(1987) [PubMed: 2823269] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2). Tissue: Brain. [5] \" Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. \" Ansari-Lari M. A. Oeltjen J. C. Schwartz S. Zhang Z. Muzny D. M. Lu J. Gorrell J. H. Chinault A. C. Belmont J. W. Miller W. Gibbs R. A. Genome Res. 8:29-40(1998) [PubMed: 9445485] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Mammary gland. [7] \" The L3T4 antigen in mouse and the sheep equivalent are immunoglobulin-like. \" Classon B. J. Tsagaratos J. Kirszbaum L. Maddox J. McKay C. R. Brandon M. McKenzie I. F. C. Walker I. D. Immunogenetics 23:129-132(1986) [PubMed: 3082751] [Abstract]Cited for: PROTEIN SEQUENCE OF 27-43. [8] \" Partial primary structure of the T4 antigens of mouse and sheep: assignment of intrachain disulfide bonds. \" Classon B. J. Tsagaratos J. McKenzie I. F. C. Walker I. D. Proc. Natl. Acad. Sci. U. S. A. 83:4499-4503(1986) [PubMed: 3086886] [Abstract]Cited for: DISULFIDE BONDS.