GOAT ANTI HUMAN CD137:Biotin

CD137

Phosphate buffered saline pH7. 2

Recombinant human CD137

Receptor for TNFSF14/4-1BBL. Possibly active during T cell activation. Subunit structureInteracts with TRAF1 TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Ref. 9Ref. 10Ref. 11Subcellular locationMembrane; Single-pass type I membrane protein. Tissue specificityExpressed on the surface of activated T-cells. Sequence similaritiesContains 4 TNFR-Cys repeats. 1. Phillips J. et al. (1996) CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A HLA-B and HLA-C allotypes. Immunity. 5: 163 - 172. 2. Braud V. et al. (1998) HLA-E binds to natural killer cell receptors CD94/NKG2A B and C. Nature. 391: 795 - 799. 3. Tomasec P. et al. (2000) Surface expression of HLA-E an inhibitor of natural killer cells enhanced by human cytomegalovirus gpUL40. Science. 287: 1031 - 1033. 4. Sö derströ m K. et al. (1997) CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. J. Immunol. 159: 1072 - 1075. [1] \" Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. \" Chang C. Rodriguez A. Carretero M. Lopez-Botet M. Phillips J. H. Lanier L. L. Eur. J. Immunol. 25:2433-2437(1995) [PubMed: 7589107] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Blood. [2] \" Structure of the human CD94 C-type lectin gene. \" Rodriguez A. Carretero M. Glienke J. Bellon T. Ramirez A. Lehrach H. Francis F. Lopez-Botet M. Immunogenetics 47:305-309(1998) [PubMed: 9472066] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta. [3] Biassoni R. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE (ISOFORM 2). [4] \" A alternatively spliced form of the human CD94 gene. \" Furukawa H. Yabe T. Watanabe K. Miyamoto R. Akaza T. Tadokoro K. Tohma S. Inoue T. Yamamoto K. Juji T. Immunogenetics 48:87-88(1998) [PubMed: 9601951] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 3). [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood. [6] \" Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. \" Boyington J. C. Riaz A. N. Patamawenu A. Coligan J. E. Brooks A. G. Sun P. D. Immunity 10:75-82(1999) [PubMed: 10023772] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 6 ANGSTROMS) OF 52-179 DISULFIDE BONDS. [7] \" The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. \" Sullivan L. C. Clements C. S. Beddoe T. Johnson D. Hoare H. L. Lin J. Huyton T. Hopkins E. J. Reid H. H. Wilce M. C. Kabat J. Borrego F. Coligan J. E. Rossjohn J. Brooks A. G. Immunity 27:900-911(2007) [PubMed: 18083576] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 5 ANGSTROMS) OF 57-179 IN COMPLEX WITH NGK2A SUBUNIT DISULFIDE BONDS. [8] \" Structural basis for NKG2A/CD94 recognition of HLA-E. \" Kaiser B. K. Pizarro J. C. Kerns J. Strong R. K. Proc. Natl. Acad. Sci. U. S. A. 105:6696-6701(2008) [PubMed: 18448674] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (4. 41 ANGSTROMS) OF 59-179 IN COMPLEX WITH NGK2A SUBUNIT DISULFIDE BONDS. [9] \" CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. \" Petrie E. J. Clements C. S. Lin J. Sullivan L. C. Johnson D. Huyton T. Heroux A. Hoare H. L. Beddoe T. Reid H. H. Wilce M. C. Brooks A. G. Rossjohn J. J. Exp. Med. 205:725-735(2008) [PubMed: 18332182] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (3. 4 ANGSTROMS) OF 57-179 IN COMPLEX WITH NGK2A SUBUNIT DISULFIDE BONDS.