Mouse Anti-Human Bax

Mouse IgG1

KLH-conjugated peptide corresponding to amino acids 3-16 near the N-terminus of human Bax ^1

Human Bax (Mr 21 kDa)Apoptosis or programmed cell death is a well-documented phenomenon in many cellular systems. ^2 It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation cytokine treatment antigen-receptor engagement cell-cell interactions irradiation and glucocorticoid treatment. 3 Bax is a member of the Bcl-2 family of apoptosis-associated proteins and although it is similar in structure to Bcl-2 Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial membranes inducing mitochondrial damage and subsequent cell death in a caspase-independent manner presumably via their ion channel-forming activity. These channels may then function to promote a mitochondrial permeability transition or to puncture the outer mitochondrial membrane. In addition to forming homodimer Bax can heterodimerize with Bcl-2 and Bcl-XL proteins. This heterodimerization between pro- and anti-apoptotic family members may serve a titration function and act as a sensor for the programmed cell death program. 4-13 Mab 2D2 is specific for human Bax. ^1

1 ug/ml

Homodimers and heterodimers with BCL2 E1B 19K protein BCL2L1 isoform Bcl-X(L) MCL1 and A1. Binds SH3GLB1 (By similarity).

Expressed in a wide variety of tissues with highest levels in the testis and ovary.

Belongs to the Bcl-2 family. Hsu Y. T. and R. J. Youle. 1997. J. Biol. Chem. 272:13829. Cohen J. J. 1991. Adv. Immunol. 50:55. Cohen J. J. and R. C. Duke. 1992. Annu. Rev. Immunol. 10:2676. Nunez G. and M. F. Clarke. 1994. Trends Cell Biol. 4:399. Cory S. 1995. Annu. Rev. Immunol. 13:513. Oltvai. Z. N. C. L. Millman and S. J. Korsmeyer. 1993. Cell 74:609. Farrow S. N. et al. 1995. Nature 374:731. Chittenden T. et al. 1995. Nature 374:733. Kiefer M. C. et al. 1995. Nature 374:736. Shimizu S. et al. 1995. Nature 374:811. Yin X. M. Z. N. Oltvai and S. J. Korsmeyer. 1994. Nature 369:321. Cheng E. H. -Y. et al. 1996. Nature 379:554. Gottschalk A. R. L. H. Boise Z. N. Oltvai M. A. Accavitti S. J. Korsmeyer J. Quintans and C. B. Thompson. 1996. Cell Death and Differentiation 3:113.