Mouse Anti-Human CD62E (E-selectin)

GWB-71ECDB

1. 2B6

Human CD62E/E-selectinCD62E represents the 100-110 kDa type I transmembrane glycoprotein E-selectin also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1). It is expressed on cytokine-stimulated endothelium weakly on unactivated endothelium and is absent on leukocytes. Like other selectins CD62E is an adhesion molecule that contributes to the initial attachment and rolling of leukocytes on endothelial surfaces a prerequisite for leukocyte extravasation into tissues. ^1-4

Reagents contain sodium azide which is very toxic if ingested or inhaled. Avoid contact with skin eyes or clothing. Wear eye or face protection when handling. If skin or eye contact occurs wash with copious amounts of water. If ingested or inhaled contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction (By similarity).

Important in acute cellular allograft rejection and probably also in xenograft rejection.

Contains 1 C-type lectin domain.

Contains 4 Sushi (CCP/SCR) domains. Schlossman S. L. Bloumsell W. Gilks J. M. Harlan C. Kishimoto J. Ritz S. Shaw R. Silverstein T. Springer T. F. Tedder and R. F. Todd eds. 1995. Leukocyte Typing V: White Cell Differentiation Antigens Oxford University Press Oxford. Gearing A. J. H. and W. Newman. 1993. Immunol. Today 14:506. Barclay A. N. M. H. Brown S. K. A. Law A. J. McKnight M. G. Tomlinson and P. A. van der Merwe eds. 1997. The Leukocyte Antigens Facts Book 2nd Edition CD62E Section Academic Press New York p. 295. Tedder T. F. D. A. Steeber A. Chen and P. Engel. 1995. FASEB J. 9:866.