MOUSE ANTI HUMAN CD54:RPE

GWB-FA6A1E

IgG1

Recognises the human CD54 cell surface antigen a 90kD glycoprotein also known as ICAM-1. CD54 is expressed by many cells following activation by inflammatory mediators. Clone 15. 2 is reported to block CD54 function (2). AbD Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:RPE

Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria. Sequence similaritiesBelongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. 1. Maglione D. et al. (1991) Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. P. N. A. S. 88: 9267-9271. [1] \" Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. \" Maglione D. Guerriero V. Viglietto G. Delli-Bovi P. Persico M. G. Proc. Natl. Acad. Sci. U. S. A. 88:9267-9271(1991) [PubMed: 1924389] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLGF-1). Tissue: Placenta. [2] \" A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta. \" Hauser S. D. Weich H. A. Growth Factors 9:259-268(1993) [PubMed: 8148155] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PLGF-2). Tissue: Placenta. [3] \" Two alternative mRNAs coding for the angiogenic factor placenta growth factor (PlGF) are transcribed from a single gene of chromosome 14. \" Maglione D. Guerriero V. Viglietto G. Ferraro M. G. Aprelikova O. Alitalo K. del Vecchio S. Lei K. -J. Chou J. Y. Persico M. G. Oncogene 8:925-931(1993) [PubMed: 7681160] [Abstract]Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM PLGF-2). [4] \" Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing. \" Cao Y. Ji W. -R. Qi P. Rosin A. Cao Y. Biochem. Biophys. Res. Commun. 235:493-498(1997) [PubMed: 9207183] [Abstract]Cited for: NUCLEOTIDE SEQUENCE (ISOFORM PLGF-3). Tissue: Placenta. [5] \" The DNA sequence and analysis of human chromosome 14. \" Heilig R. Eckenberg R. Petit J. -L. Fonknechten N. Da Silva C. Cattolico L. Levy M. Barbe V. De Berardinis V. Ureta-Vidal A. Pelletier E. Vico V. Anthouard V. Rowen L. Madan A. Qin S. Sun H. Du H. Pepin K. Artiguenave F. Robert C. Cruaud C. Bruels T. Jaillon O. Friedlander L. Samson G. Brottier P. Cure S. Segurens B. Aniere F. Samain S. Crespeau H. Abbasi N. Aiach N. Boscus D. Dickhoff R. Dors M. Dubois I. Friedman C. Gouyvenoux M. James R. Madan A. Mairey-Estrada B. Mangenot S. Martins N. Menard M. Oztas S. Ratcliffe A. Shaffer T. Trask B. Vacherie B. Bellemere C. Belser C. Besnard-Gonnet M. Bartol-Mavel D. Boutard M. Briez-Silla S. Combette S. Dufosse-Laurent V. Ferron C. Lechaplais C. Louesse C. Muselet D. Magdelenat G. Pateau E. Petit E. Sirvain-Trukniewicz P. Trybou A. Vega-Czarny N. Bataille E. Bluet E. Bordelais I. Dubois M. Dumont C. Guerin T. Haffray S. Hammadi R. Muanga J. Pellouin V. Robert D. Wunderle E. Gauguet G. Roy A. Sainte-Marthe L. Verdier J. Verdier-Discala C. Hillier L. W. Fulton L. McPherson J. Matsuda F. Wilson R. Scarpelli C. Gyapay G. Wincker P. Saurin W. Quetier F. Waterston R. Hood L. Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM PLGF-1). [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PLGF-2). Tissue: Muscle and Placenta. [7] \" Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity in vitro and in vivo and high affinity binding to Flt-1 but not to Flk-1/KDR. \" Park J. E. Chen H. H. Winer J. Houck K. A. Ferrara N. J. Biol. Chem. 269:25646-25654(1994) [PubMed: 7929268] [Abstract]Cited for: CHARACTERIZATION PROTEIN SEQUENCE OF 19-24. [8] \" The crystal structure of human placenta growth factor-1 (PlGF-1) an angiogenic protein at 2. 0 A resolution. \" Iyer S. Leonidas D. D. Swaminathan G. J. Maglione D. Battisti M. Tucci M. Persico M. G. Acharya K. R. J. Biol. Chem. 276:12153-12161(2001) [PubMed: 11069911] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 0 ANGSTROMS) (ISOFORM PLGF-1).