MOUSE ANTI HUMAN PLASMINOGEN

GWB-5F42D7

IgG2b

Phosphate buffered saline pH7. 4

Purified human plasminogen

Does not cross-react with other human serum proteins. Recommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGRabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgGGoat Anti Mouse IgG IgA IgMRabbit Anti Mouse IgGHuCAL Anti Mouse IgG2bGoat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)

Kringle domains mediate interaction with CSPG4. Ref. 23Post-translational modificationN-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity). In the presence of the inhibitor the activation involves only cleavage after Arg-580 yielding two chains held together by two disulfide bonds. In the absence of the inhibitor the activation involves additionally the removal of the activation peptide. Involvement in diseaseDefects in PLG are a cause of susceptibility to thrombosis (THR) [MIM:188050]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Ref. 43Ref. 46Ref. 47Ref. 48Defects in PLG are the cause of plasminogen deficiency (PLGD) [MIM:217090]. PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms whereas type 2 deficiency also known as dysplasminogenemia is characterized by normal or slightly reduced antigen levels and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white yellow-white or red thick masses with a wood-like consistency that replace the normal mucosa. Ref. 43Ref. 46Ref. 47Ref. 48Ref. 45Ref. 49Ref. 50Ref. 51Miscellaneous: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot. Sequence similaritiesBelongs to the peptidase S1 family. Plasminogen subfamily. Contains 5 kringle domains. Contains 1 PAN domain. Contains 1 peptidase S1 domain. 1. Moussad E. E-D. A. and Brigstock D. R. (2000) Connective tissue growth factor: What\' s in a name? Mol. Genet. Metab. 71: 276-292. 2. Westermann D. et al. (2009) Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy. Diabetes. 58:1373-81. [1] \" Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. \" Bradham D. M. Igarashi A. Potter R. L. Grotendorst G. R. J. Cell Biol. 114:1285-1294(1991) [PubMed: 1654338] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT ASP-83. Tissue: Umbilical vein endothelial cell. [2] \" Connective tissue growth factor. \" Igarashi A. Bradham D. M. Okochi H. Grotendorst G. R. J. Dermatol. 19:642-643(1992) [PubMed: 1293144] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT ASP-83. Tissue: Umbilical vein endothelial cell. [3] \" Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. \" Oemar B. S. Werner A. Garnier J. -M. Do D. D. Godoy N. Nauck M. Marz W. Rupp J. Pech M. Luescher T. F. Circulation 95:831-839(1997) [PubMed: 9054739] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT ASP-83. Tissue: Aorta. [4] \" Expression purification and bio-activity of human connective tissue growth factor. \" Li Q. -H. Wang L. -C. Liu L. -D. Dong S. -Z. Wang J. -J. Hu F. Wang J. He S. -Q. Dong C. -H. Zhao S. -D. Zhao H. -L. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT ASP-83. [5] \" Complete mRNA sequence of human connective tissue growth factor. \" Dai W. -J. Jiang H. -C. Fu S. -B. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT ASP-83. Tissue: Liver. [6] \" Cloning of human full-length CDSs in BD Creator(TM) system donor vector. \" Kalnine N. Chen X. Rolfs A. Halleck A. Hines L. Eisenstein S. Koundinya M. Raphael J. Moreira D. Kelley T. LaBaer J. Lin Y. Phelan M. Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) VARIANT ASP-83. [7] \" Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201). \" Halleck A. Ebert L. Mkoundinya M. Schick M. Eisenstein S. Neubert P. Kstrang K. Schatten R. Shen B. Henze S. Mar W. Korn B. Zuo D. Hu Y. LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) VARIANT ASP-83. [8] \" The DNA sequence and analysis of human chromosome 6. \" Mungall A. J. Palmer S. A. Sims S. K. Edwards C. A. Ashurst J. L. Wilming L. Jones M. C. Horton R. Hunt S. E. Scott C. E. Gilbert J. G. R. Clamp M. E. Bethel G. Milne S. Ainscough R. Almeida J. P. Ambrose K. D. Andrews T. D. Ashwell R. I. S. Babbage A. K. Bagguley C. L. Bailey J. Banerjee R. Barker D. J. Barlow K. F. Bates K. Beare D. M. Beasley H. Beasley O. Bird C. P. Blakey S. E. Bray-Allen S. Brook J. Brown A. J. Brown J. Y. Burford D. C. Burrill W. Burton J. Carder C. Carter N. P. Chapman J. C. Clark S. Y. Clark G. Clee C. M. Clegg S. Cobley V. Collier R. E. Collins J. E. Colman L. K. Corby N. R. Coville G. J. Culley K. M. Dhami P. Davies J. Dunn M. Earthrowl M. E. Ellington A. E. Evans K. A. Faulkner L. Francis M. D. Frankish A. Frankland J. French L. Garner P. Garnett J. Ghori M. J. Gilby L. M. Gillson C. J. Glithero R. J. Grafham D. V. Grant M. Gribble S. Griffiths C. Griffiths M. N. D. Hall R. Halls K. S. Hammond S. Harley J. L. Hart E. A. Heath P. D. Heathcott R. Holmes S. J. Howden P. J. Howe K. L. Howell G. R. Huckle E. Humphray S. J. Humphries M. D. Hunt A. R. Johnson C. M. Joy A. A. Kay M. Keenan S. J. Kimberley A. M. King A. Laird G. K. Langford C. Lawlor S. Leongamornlert D. A. Leversha M. Lloyd C. R. Lloyd D. M. Loveland J. E. Lovell J. Martin S. Mashreghi-Mohammadi M. Maslen G. L. Matthews L. McCann O. T. McLaren S. J. McLay K. McMurray A. Moore M. J. F. Mullikin J. C. Niblett D. Nickerson T. Novik K. L. Oliver K. Overton-Larty E. K. Parker A. Patel R. Pearce A. V. Peck A. I. Phillimore B. J. C. T. Phillips S. Plumb R. W. Porter K. M. Ramsey Y. Ranby S. A. Rice C. M. Ross M. T. Searle S. M. Sehra H. K. Sheridan E. Skuce C. D. Smith S. Smith M. Spraggon L. Squares S. L. Steward C. A. Sycamore N. Tamlyn-Hall G. Tester J. Theaker A. J. Thomas D. W. Thorpe A. Tracey A. Tromans A. Tubby B. Wall M. Wallis J. M. West A. P. White S. S. Whitehead S. L. Whittaker H. Wild A. Willey D. J. Wilmer T. E. Wood J. M. Wray P. W. Wyatt J. C. Young L. Younger R. M. Bentley D. R. Coulson A. Durbin R. M. Hubbard T. Sulston J. E. Dunham I. Rogers J. Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [9] \" Differential expression of novH and CTGF in human glioma cell lines. \" Xin L. W. Martinerie C. Zumkeller W. Westphal M. Perbal B. Clin. Mol. Pathol. 49:91-97(1996)Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20. Tissue: Placenta. [10] \" Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms. \" Blom I. E. van Dijk A. J. de Weger R. A. Tilanus M. G. J. Goldschmeding R. J. Clin. Pathol. 54:192-196(2001)Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.