MOUSE ANTI HUMAN CD54:Low Endotoxin

CD54

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Recognises the human CD54 cell surface antigen a 90kD glycoprotein also known as ICAM-1 expressed by many cells following activation by inflammatory mediators. Clone 15. 2 is reported to block CD54 function (2). Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:Low EndotoxinRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)

Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria. Sequence similaritiesBelongs to the immunoglobulin superfamily. ICAM family. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. 1. Gomes A. V. et al. (2002) The role of troponins in muscle contraction. IUBMB Life. 54: 323-333. [1] \" The amino acid sequence of human cardiac troponin-C. \" Roher A. Lieska N. Spitz W. Muscle Nerve 9:73-77(1986) [PubMed: 3951483] [Abstract]Cited for: PROTEIN SEQUENCE. Tissue: Heart muscle. [2] \" Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. \" Gahlmann R. Wade R. Gunning R. Kedes L. J. Mol. Biol. 201:379-391(1988) [PubMed: 3166492] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Slow skeletal muscle. [3] \" Cloning structural analysis and expression of the human slow twitch skeletal muscle/cardiac troponin C gene. \" Schreier T. Kedes L. Gahlmann R. J. Biol. Chem. 265:21247-21253(1990) [PubMed: 2250022] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Slow skeletal muscle. [4] \" H. sapiens mRNA for cardiac ventricular troponin C in idiopathic dilated cardiomyopathy. \" Margossian S. S. Yang F. Umeda P. K. Sciaky D. Anderson P. A. W. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood. [6] \" Calcium-induced structural transition in the regulatory domain of human cardiac troponin C. \" Spyracopoulos L. Li M. X. Sia S. K. Gagne S. M. Chandra M. Solaro R. J. Sykes B. D. Biochemistry 36:12138-12146(1997) [PubMed: 9315850] [Abstract]Cited for: STRUCTURE BY NMR OF 1-89. Tissue: Heart muscle. [7] \" Structural and functional domains of the troponin complex revealed by limited digestion. \" Takeda S. Kobayashi T. Taniguchi H. Hayashi H. Maeda Y. Eur. J. Biochem. 246:611-617(1997) [PubMed: 9219516] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2. 61 ANGSTROMS). [8] \" Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I. \" Lindhout D. A. Sykes B. D. J. Biol. Chem. 278:27024-27034(2003) [PubMed: 12732641] [Abstract]Cited for: STRUCTURE BY NMR OF 89-161. Tissue: Heart muscle. [9] \" First mutation in cardiac troponin C L29Q in a patient with hypertrophic cardiomyopathy. \" Hoffmann B. Schmidt-Traub H. Perrot A. Osterziel K. J. Gessner R. Hum. Mutat. 17:524-524(2001) [PubMed: 11385718] [Abstract]Cited for: VARIANT CMH13 GLN-29. [10] \" Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. \" Mogensen J. Murphy R. T. Shaw T. Bahl A. Redwood C. Watkins H. Burke M. Elliott P. M. McKenna W. J. J. Am. Coll. Cardiol. 44:2033-2040(2004) [PubMed: 15542288] [Abstract]Cited for: VARIANT CMD1Z ARG-159.