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RABBIT ANTI HUMAN TRPA1

RABBIT ANTI HUMAN TRPA1

Item no.	18-783-313723
Manufacturer	GENWAY
Amount	0.05 mg
Category	Oncology Antibodies Primary Antibodies By Organ Skin Cancer
Type	Antibody
Specific against	Human
Host	Rabbit
ECLASS 5.1	32160702
ECLASS 6.1	32160702
ECLASS 8.0	32160702
ECLASS 9.0	32160702
ECLASS 10.0.1	32160702
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3E2B96
Similar products	18-783-313723
Available
Genway ID:	GWB-3E2B96
Specificity:	TRPA1
Isotype:	Polyclonal IgG
Buffer Solution:	Phosphate buffered saline pH7. 7
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:	Synthetic peptide: internal domain of human TRPA1 conjugated to Keyhole Limpet Hemocyanin (KLH).
Specificity:	Detects Transient receptor potential A1 (TRPA1) an excitatory cation channel that is highly expressed in nociceptive neurons and plays an important role in inflammatory pain. TRPA1 mediates the response to the proalgesic bradykinin as well as to pungent irritants found in mustards garlic and cinnamon. TRPA1 may also be involved in hearing (as the mammalian hair cell mechanotransducer) and in the detection of cold stimuli. Recommended Secondary Antibodies: Sheep Anti Rabbit IgGGoat Anti Rabbit IgG (Fc)Goat Anti Rabbit IgG (H/L)
Function:	Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants such as mustard oil garlic and acrolein an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC) the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system By similarity. Subcellular locationMembrane; Multi-pass membrane protein Probable. Tissue specificityExpressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. Ref. 1Miscellaneous: Inhibited by ruthenium red a potent blocker of TRPV channels By similarity. Sequence similaritiesBelongs to the transient receptor (TC 1. A. 4) family. [View classification]Contains 15 ANK repeats. [1] \" The murine homologue of the T lymphocyte CD2
Antigen:	molecular cloning chromosome assignment and cell surface expression. \" Sewell W. A. Brown M. H. Fink P. J. Kozak C. A. Crumpton M. J. Eur. J. Immunol. 17:1015-1020(1987) [PubMed: 2440689] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: B10. A. [2] \" Murine and human T11 (CD2) cDNA sequences suggest a common signal transduction mechanism. \" Clayton L. K. Sayre P. H. Novotny J. Reinherz E. L. Eur. J. Immunol. 17:1367-1370(1987) [PubMed: 2820751] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [3] \" Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes. \" Diamond D. J. Clayton L. K. Sayre P. H. Reinherz E. L. Proc. Natl. Acad. Sci. U. S. A. 85:1615-1619(1988) [PubMed: 2894031] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c. Tissue: Liver. [4] \" Molecular cloning of the murine homologue of CD2. Homology of the molecule to its human counterpart T11. \" Yagita H. Okumura K. Nakauchi H. J. Immunol. 140:1321-1326(1988) [PubMed: 3257775] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [5] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Hematopoietic. [6] \" A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. \" Dustin M. L. Olszowy M. W. Holdorf A. D. Li J. Bromley S. Desai N. Widder P. Rosenberger F. van der Merwe P. A. Allen P. M. Shaw A. S. Cell 94:667-677(1998) [PubMed: 9741631] [Abstract]Cited for: INTERACTION WITH CD2AP. [7] \" The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. \" Badour K. Zhang J. Shi F. McGavin M. K. H. Rampersad V. Hardy L. A. Field D. Siminovitch K. A. Immunity 18:141-154(2003) [PubMed: 12530983] [Abstract]Cited for: INTERACTION WITH PSTPIP1.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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