RABBIT ANTI HUMAN DEFENSIN BETA 3

DEFENSIN BETA 3

Phosphate buffered saline pH7. 2

Recombinant human defensin beta 3

Exhibits antimicrobial activity against Gram-positive bacteria S. aureus and S. pyogenes Gram-negative bacteria P. aeruginosa and E. coli and the yeast C. albicans. Kills multiresistant S. aureus and vancomycin-resistent E. faecium. No significant hemolytic activity was observed. Ref. 1Subcellular locationSecreted. Tissue specificityHighly expressed in skin and tonsils and to a lesser extent in trachea uterus kidney thymus adenoid pharynx and tongue. Low expression in salivary gland bone marrow colon stomach polyp and larynx. No expression in small intestine. Ref. 1Induction: By infection of bacteria and by interferon gamma. Ref. 1Sequence similaritiesBelongs to the beta-defensin family. Mass spectrometryMolecular mass is 5154. 59 Da from positions 23 - 67. Determined by ESI. Ref. 1