RABBIT ANTI HUMAN CD279

CD279

Phosphate buffered saline

A peptide corresponding to a 16 amino acid sequence from near the centre of Human CD279.

Possible cell death inducer in association with other factors. Subunit structureMonomer By similarity. Subcellular locationMembrane; Single-pass type I membrane protein. Developmental stageInduced at programmed cell death. Involvement in diseaseGenetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin joints kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Ref. 4Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Cobbold S. and Metcalfe S. (1994) Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens 43: 137-154. 2. Hewicker - Trautwein M. et al. (1999) Immunocytochemical demonstration of lymphocyte subsets and MHC class II antigen expression in synovial membranes from dogs with rheumatoid arthritis and degenerative joint disease. Vet. Immunol. Immunopathol. 67: 341-357.