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Endostatin, Human

Endostatin, Human

Item no.	Z02533-20
Manufacturer	GenScript
Amount	20ug
Category	Oncology Neuroscience Neural Lineage Markers Neural Adhesion Molecules By Cell Type Carcinoma Hematology Leukemia Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Adenocarcinoma Cell Stainings ECM Cardiovascular Research Ischemia & Reperfusion Injury By Organ Lung Cancer Bladder Cancer
Type	Proteins
Specific against	Human
Purity	Greater than 97% by SDS-PAGE
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02533-Endostatin, Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.</td></tr><tr><th>Purity</th><td colspan="7"> Greater than 97% by SDS-PAGE</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Endotoxin level is less than 0.1 ng per ug (1EU/ug) of Endostatin.</td></tr><tr><th>Specific Activity</th><td colspan="7"> Determined by Endothelial Cell Tube Formation. The cells treated with 10&
Similar products	Endostatin
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Specificity	Determined by Endothelial Cell Tube Formation. The cells treated with 10μ,g/ml Endostatin showed significant anti-angiogenesis effect.
Specificity	Determined by Endothelial Cell Tube Formation. The cells treated with 10μ, g/ml Endostatin showed significant anti-angiogenesis effect.
Description	Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Endotoxin Level	Endotoxin level is less than 0.1 ng per ug (1EU/ug) of Endostatin.
Formulation	The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.
Product Line	Others
Storage	The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20C. For the first use, reconstitute in water, aliquot and store at -20C to avoid multiple freeze-thaws.
Product Origin	USA

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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