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IL-16, Human

IL-16, Human

Item no.	Z02196-1
Manufacturer	GenScript
Amount	1 mg
Quantity options	1 mg 10 ug 50 ug
Category	Oncology Food Safety Neuroscience Neural Lineage Markers Aging & Neurological Disorders By Cell Type Carcinoma Melanoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Adenocarcinoma Contaminants Cell Migration & Invasion Metals By Organ Breast Cancer Heart & Blood Cancer
Type	Proteins
Specific against	Human (Homo sapiens)
Purity	Greater than 97.0% as determined by (a) RP-HPLC analysis, (b) Anion-exchange FPLC (c) Reducing and non-reducing SDS-PAGE Silver Stained gel analysis
Sequence	The sequence of the first five N-terminal amino acids was determined and was found to be Met-Pro-Asp-Leu-Asn.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02196-Interleukin_16_IL_16_human, IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity. GenScript, Interleukin (IL)-16, human, produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 13,400 Da.</td></tr><tr><th>M.W.</th><td colspan="7"> 13,400 Da</td></tr><tr><th>Purity</th><td colspan="7"> Greater than 97.0% as determined by (a) RP-HPLC analysis, (b) Anion-exchange FPLC (c) Reducing and non-reducing SDS-PAGE Silver Stained gel analysis</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.1 ng/ug (1 IEU/ug) determined by LAL test</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized rHuIL-16 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution rHuIL-16 should be stored at 4C between 2-7 days and for future use below -18C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.</td></tr><tr><th>Specificity</th><td colspan="7"> rHuIL-16 is fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a specific activity greater than 1.0×104 IU/mg.</td></tr><tr><th>Formulation</th><td colspan="7"> rHuIL-16 was lyophilized from 1 mg/ml solution after extensive dialysis against 20 mM acetic buffer, pH 5.0, 150 mM NaCl and 0.5 mM DTT.</td></tr><tr><th>Reconstitution</th><td colspan="7"> It is recommended to reconstitute the lyophilized rHuIL-16 in sterile 18 M&
Similar products	Interleukin-16
Shipping condition	Cool pack
Available
Specificity	rHuIL-16 is fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a specific activity greater than 1.0x104 IU/m
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	13, 400 Da
Product Line	Cytokines
Manufacturer - Specificity	rHuIL-16 is fully biologically active when compared to standard. The ED50 as determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 10.0-100.0 ng/ml, corresponding to a specific activity greater than 1.0x104 IU/mg.
Description	IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, human IL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4+ T cells. Human and murine IL-16 show significant cross-species reactivity. GenScript, Interleukin (IL)-16, human, produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 13, 400 Da.
Reconstitution	It is recommended to reconstitute the lyophilized rHuIL-16 in sterile 18 MΩ, -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Formulation	rHuIL-16 was lyophilized from 1 mg/ml solution after extensive dialysis against 20 mM acetic buffer, pH 5.0, 150 mM NaCl and 0.5 mM DTT.
Endotoxin Level	Less than 0.1 ng/ug (1 IEU/ug) determined by LAL test

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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