Human beta-Amyloid 1-40 Antibody (4A4F2), mAb, Mouse

GenScript Human beta-Amyloid 1-40 Antibody (4A4F2), mAb, Mouse, detects human beta-Amyloid 1-40 and does not cross-react with human beta-Amyloid 1-42.

A number of mutations, identified in the gene encoding the beta-amyloid precursor protein (betaAPP), have been linked to early-onset Familial Alzheimer's Disease. betaAPP is cleaved sequentially by the proteolytic enzymes beta-secretase and gamma-secretase to produce beta-amyloid (Abeta) peptides with the Abeta1-42(43) and the Abeta1-40 forms being the most prevalent. Secreted Abeta peptides can bind to scavenger receptors and the receptor for advanced glycation end- products. Abeta peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of Abeta leads to formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimer’s disease. beta-amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.

synthetic peptide corresponding to amino acids 32-40 of beta-Amyloid C-terminus conjugated to KLH (Swiss Prot: P05067)

Reconstitute lyophilized powder with deionized water (or equivalent) to antibody concentration of 0.5 mg/ml.

GenScript Human beta-Amyloid 1-40 Antibody (4A4F2), mAb, Mouse, should be stored lyophilized until use. It remains stable in lyophilized form if stored at -20C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8C or for up to 12 months at -20C or below. Avoid repeated freezing and thawing cycles.