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SOX 10 predilute

SOX 10 predilute

Item no.	GME-IHC010-7
Manufacturer	GenomeMe
Amount	7ml
Category	Oncology Antibodies Primary Antibodies By Organ Skin Cancer
Type	Antibody Monoclonal
Clone	IHC010
Specific against	Human (Homo sapiens)
Host	Mouse
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Available
Description	SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.
CE	CE, IVD
Positive Control	Melanoma, Skin Melanocytes
Source	Mouse Monoclonal
Dilution Range	1:100 - 1:200
References	Pingault V, et al. Nat Genet. 1998; 18:171-3. Bondurand N, et al. Hum Mol Genet. 2000; 8:1785-9. Kelsch RN. BioEssays. 2006; 28:788. Nonaka D, et al. Am J Surg Pathol. 2008; 32:1291-8. Chorny JA, et al. Am J Dermatopathol. 2002; 24:309-12. Robson A, et al. Histopathology. 2001; 38:135-40. Longacre T, et al. Am J Surg Pathol. 1996; 20:1489-500. Ramos-Herberth FI, et al. J Cutan Pathol. 2010; 37:944–52.

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GME-IHC010-7-safety-datasheet.pdf