Item no. |
E91171 |
Manufacturer |
Enogene
|
Amount |
100ul |
Category |
|
Type |
Antibody |
Applications |
Western Blot, Immunohistochemistry |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
ARRB2, ARB2, ARR2, BARR2, DKFZp686L0365 , Beta Arrestin 2 |
Available |
|
Background |
Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling (1). Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as beta-arrestin 1) and arrestin 3 (beta-arrestin 2) are ubiquitously expressed and bind to most GPCRs (2). beta-arrestins function as adaptor and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in Erk activation pathways (3, 4). beta-arrestins are also involved in some receptor tyrosine kinase signaling pathways (5-8). Additional evidence suggests that beta-arrestins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors (9, 10). |
Research Area |
Autophagy antibody, Cancer, Cardiovascular, Cell Biology, Epigenetics and Nuclear Signaling, Developmental Biologys, Immunology, Drug Discovery Products, Metabolism, Neuroscience, Signal Transduction, Stem Cells |
Swiss-Prot No. |
P32121 |
Altername |
ARRB2, ARB2, ARR2, BARR2, DKFZp686L0365 , Beta Arrestin 2 |
Immunogen |
Recombinant proteinof human ARRB2 |
Purification |
Affinity purification |
Applications information |
WB IHC |
Gene ID |
409 |
Molecular Weight |
46kDa |
Storage/Stability |
Store at -20C or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.