Item no. |
E90027 |
Manufacturer |
Enogene
|
Amount |
100ul |
Category |
|
Type |
Antibody |
Applications |
Western Blot, Immunohistochemistry |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
STAT1, DKFZp686B04100, ISGF-3, STAT91 , |
Similar products |
CASP7 |
Available |
|
Background |
The Stat1 transcription factor is activated in response to a large number of ligands (1) and is essential for responsiveness to IFN-alpha and IFN-gamma (2, 3). Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding (4). Stat1 protein exists as a pair of isoforms, Stat1alpha (91 kDa) and the splice variant Stat1beta (84 kDa). In most cells, both isoforms are activated by IFN-alpha, but only Stat1alpha is activated by IFN-gamma. The inappropriate activation of Stat1 occurs in many tumors (5). In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-alpha and other cellular stresses (6). Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation. |
Research Area |
Autophagy antibody, Cancer, Cardiovascular, Cell Biology, Epigenetics and Nuclear Signaling, Developmental Biologys, Immunology, Drug Discovery Products, Metabolism, Neuroscience, Signal Transduction, Stem Cells |
Swiss-Prot No. |
P42224 |
Altername |
STAT1, DKFZp686B04100, ISGF-3, STAT91 , |
Immunogen |
Recombinant protein of human STAT1 |
Purification |
Affinity purification |
Applications information |
WB IHC |
Gene ID |
6772 |
Molecular Weight |
83kDa |
Storage/Stability |
Store at -20C or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.