Item no. |
E10-20134 |
Manufacturer |
Enogene
|
Amount |
100ug/100ul |
Category |
|
Type |
Antibody |
Applications |
ELISA, Western Blot |
Specific against |
Human |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DKFZp686D0638, GSK3A |
Similar products |
GSK3 alpha |
Available |
|
Background |
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility. |
Research Area |
Autophagy antibody, Cancer, Cardiovascular, Cell Biology, Epigenetics and Nuclear Signaling, Developmental Biologys, Immunology, Drug Discovery Products, Metabolism, Neuroscience, Signal Transduction, Stem Cells |
Form of Antibody |
Ascitic fluid containing 0.03% sodium azide. |
Altername |
DKFZp686D0638, GSK3A |
Immunogen |
Purified recombinant fragment of GSK3 alpha expressed in E. Coli. |
Applications information |
WB, ELISA. Not yet tested in other applications. Determining optimal working dilutions by titration test. |
Recommended Dilutions |
WB:1/500 - 1/2000 , ELISA: Propose dilution 1/10000. |
Storage/Stability |
Store at 4C, for long term storage, store at -20C |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.