Item no. |
E-AB-31399-20 |
Manufacturer |
Elabscience
|
Amount |
20uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
FADK 1, FADK, FAK related non kinase polypeptide, FAK1, FAK1, Focal adhesion kinase 1, Focal adhesion Kinase, Focal adhesion kinase isoform FAK Del33, Focal adhesion kinase related nonkinase, FRNK, p125FAK, pp125FAK, PPP1R71, Protein phosphatase 1 regulat |
Similar products |
Ptk2, Focal adhesion kinase 1, Protein-tyrosine kinase 2, p125FAK, pp125FAK, FAK1, FADK, FRNK, PPP1R71, FADK 1, Protein phosphatase 1 regulatory subunit 71, FAK related non kinase polypeptide, Protein tyrosine kinase 2, PTK2 protein tyrosine kinase 2, Focal adhesion Kinase, Focal adhesion kinase isoform FAK Del33, Focal adhesion kinase related nonkinase |
Available |
|
Research Areas |
Cancer, Cardiovascular, Signal Transduction |
Synonyms |
FADK 1, FADK, FAK related non kinase polypeptide, FAK1, FAK1, Focal adhesion kinase 1, Focal adhesion Kinase, Focal adhesion kinase isoform FAK Del33, Focal adhesion kinase related nonkinase, FRNK, p125FAK, pp125FAK, PPP1R71, Protein phosphatase 1 regulatory subunit 71, Protein tyrosine kinase 2, Protein-tyrosine kinase 2, Ptk2, PTK2 protein tyrosine kinase 2 |
Swissprot |
Q05397 |
Background |
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Synthesized peptide derived from human FAK around the non-phosphorylation site of Tyr397. |
Buffer |
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
Purification Method |
Affinity purification |
Dilution |
WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000 |
Conjugation |
Unconjugated |
Calculated MW |
119kDa |
Observed MW |
119kDa |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.