Item no. |
E-AB-22036-200 |
Manufacturer |
Elabscience
|
Amount |
200uL |
Category |
|
Type |
Antibody Monoclonal |
Applications |
WB |
Clone |
8K5 |
Specific against |
Human |
Host |
Mouse |
Isotype |
IgG |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
COFS 4, COFS4, DNA excision repair protein ERCC 1, DNA excision repair protein ERCC-1, DNA excision repair protein ERCC1, ERCC 1, ERCC1, ERCC1, Excision repair cross complementation group 1, Excision repair cross complementing 1, Excision Repair Cross Com |
Similar products |
ERCC1, DNA excision repair protein ERCC-1, RAD10, COFS4, UV20, COFS 4, DNA excision repair protein ERCC 1, DNA excision repair protein ERCC1, ERCC 1, Excision repair cross complementation group 1, Excision repair cross complementing 1, Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1, Excision repair protein, RAD 10, UV 20 |
Available |
|
Research Areas |
Cancer, Epigenetics and Nuclear Signaling |
Synonyms |
COFS 4, COFS4, DNA excision repair protein ERCC 1, DNA excision repair protein ERCC-1, DNA excision repair protein ERCC1, ERCC 1, ERCC1, ERCC1, Excision repair cross complementation group 1, Excision repair cross complementing 1, Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1, Excision repair protein, RAD 10, RAD10, UV 20, UV20 |
Swissprot |
P07992 |
Background |
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Synthetic Peptide |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Protein A purification |
Dilution |
WB 1:1000-1:2000 |
Conjugation |
Unconjugated |
Calculated MW |
33kDa |
Observed MW |
36kDa |
Santa Cruz # |
sc-10157, sc-10154, sc-10785 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.