Recombinant Rat JAM-A/F11R Protein (Fc Tag)

F11R, Jam1

A DNA sequence encoding the rat F11R () was expressed, fused with the Fc region of human IgG1 at the C-terminus.

C-Fc

This product is provided as lyophilized powder which is shipped with ice packs.

< 1.0 EU per ug of the protein as determined by the LAL method

49.9 kDa

Lyophilized from sterile PBS, pH 7.4

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.