Item no. |
ELS-PKSQ050075-10ug |
Manufacturer |
Elabscience
|
Amount |
10ug |
Category |
|
Type |
Proteins |
Specific against |
other |
Host |
Human Cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, Herpesvirus Entry Mediator A, HveA, Tumor Necrosis Factor Receptor-Like 2, TR2, CD270, TNFRSF14, HVEA, HVEM |
Similar products |
TNFRSF14, TR2, HVEA, HVEM, HveA, CD270, Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, Herpesvirus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2 |
Available |
|
Synonym |
Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, Herpesvirus Entry Mediator A, HveA, Tumor Necrosis Factor Receptor-Like 2, TR2, CD270, TNFRSF14, HVEA, HVEM |
Storage |
according to manual |
Protein Construction |
Recombinant Rhesus macaque HVEM is produced by our Mammalian expression system and the target gene encoding Pro37-Val203 is expressed with a Fc tag at the C-terminus. |
Sequence |
Pro37-Val203 |
Fusion tag |
C-Fc |
Accession |
XP_005545061.1 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95% as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
44.7 kDa |
AP Mol Mass |
60 kDa |
Formulation |
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.