Recombinant Mouse Kallikrein 7/KLK7 Protein (His Tag)

Kallikrein-7, Klk7, Serine protease 6, Stratum corneum chymotryptic enzyme, Thymopsin, kallikrein-related peptidase 7, PRSS6, SCCEkallikrein-7, SCCE

Recombinant Mouse Kallikrein 7 is produced by our Mammalian expression system and the target gene encoding Gln22-Arg249 is expressed with a 6His tag at the C-terminus.

C-6His

This product is provided as lyophilized powder which is shipped with ice packs.

< 1.0 EU per ug as determined by the LAL method.

26.1 kDa

Lyophilized from a 0.2 um filtered solution of 20mM HEPES, 150mM NaCl, pH7.4.

Kallikrein7, also named as stratum corneum chymotryptic enzyme (SCCE), is a secreted protein of the Kallikrein-related peptidase (KLK) family. This family contains fifteen homologous secreted serine endopeptidases and plays a significant role in various physiological processes, including skin desquamation, semen liquefaction, neural plasticity, and body fluid homeostasis. In skin KLK5, KLK 7 and KLK14 are able to degrade corneodesmosomes, which leads to desquamation of skin surface cells. KLK activation is believed to be mediated through highly organized proteolytic cascades, regulated through a series of feedback loops, inhibitors, auto-degradation and internal cleavages. Studies have shown that one potential physiological activator for KLK7 is KLK5. Along with KLK14, these three kallikreins form a proteolytic cascade in the stratum corneum. KLK7 is primarily expressed in the skin but is also detected at relatively high levels in esophagus, heart, liver, central nervous system, kidney, pancreas, mammary and salivary glands.