Item no. |
ELS-PKSM040436-200ug |
Manufacturer |
Elabscience
|
Amount |
200ug |
Category |
|
Type |
Proteins |
Specific against |
Mouse |
Host |
HEK293 cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Tumor-associated calcium signal transducer 2,Tacstd2,Trop2,Cell surface glycoprotein Trop-2, TROP-2,C80403,EGP-1,GA733-1,Ly97 |
Similar products |
Tacstd2, Trop2, Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, EGP-1, GA733-1, TROP-2, C80403, Ly97 |
Available |
|
Synonym |
Tumor-associated calcium signal transducer 2, Tacstd2, Trop2, Cell surface glycoprotein Trop-2, TROP-2, C80403, EGP-1, GA733-1, Ly97 |
Storage |
according to manual |
Activity |
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells.When 5 x 10E4 cells/well are added to coated plates (40 ug/mL, 100 uL/well), > 50% cells will adhere after 1 hour at 37C. |
Protein Construction |
A DNA sequence encoding the extracellular domain of mouse TACSTD2 (Q8BGV3?) (Met 1-Gln 270) was fused with the Fc region of human IgG1 at the C-terminus. |
Sequence |
Met 1-Gln 270 |
Fusion tag |
C-Fc |
Accession |
Q8BGV3 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95 % as determined by SDS-PAGE |
Endotoxin |
< 1.0 EU per ug of the protein as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
55 kDa |
AP Mol Mass |
66 kDa |
Formulation |
Lyophilized from sterile PBS, pH 7.4 |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.