Recombinant Human IL1F6/IL36A Protein

according to manual

Met1-Phe158

This product is provided as lyophilized powder which is shipped with ice packs.

< 1.0 EU per ug as determined by the LAL method.

17.7 kDa

Lyophilized from a 0.2 um filtered solution of PBS; PH7.4.

Human Interleukin-36alpha (IL-36alpha) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36alpha is expressed in the immune system and the fetal brain; but not in other tissues or multiple hematopoietic cell lines. IL-36alpha is the only IL-1 family member found to be expressed on T-cells. IL-36alpha and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly; IL-36alpha inhibits PPARgamma expression; which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36alpha; along with IL-1F8 and IL-1F9; has been shown to act as an agonist by activating the pathway involving NFkappaB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36alpha may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation; recruits a second receptor as a signaling component; forming an active heterodimeric receptor complex.