Recombinant Human Semaphorin 4D/SEMA4D Protein (His Tag)

Semaphorin-4D, A8, BB18, GR3, CD100, C9orf164, CD100, coll-4, M-sema-G, SEMAJ

Recombinant Human Semaphorin 4D is produced by our Mammalian expression system and the target gene encoding Met22-Arg734 is expressed with a 6His tag at the C-terminus.

C-6His

This product is provided as lyophilized powder which is shipped with ice packs.

< 1.0 EU per ug as determined by the LAL method.

80.2 kDa

Lyophilized from a 0.2 um filtered solution of 20mM PB; 150mM NaCl; pH 7.4.

Semaphorin-4D is also known as A8; BB18; GR3; CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain; 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. It promotes the migration of cerebellar granule cells and of endothelial cells; regulates dendrite and axon branching and morphogenesis. Semaphorin-4D Plays a role in the immune system; Promotes signaling via SRC and PTK2B/PYK2; which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.