Item no. |
ELS-PKSH032864-10ug |
Manufacturer |
Elabscience
|
Amount |
10ug |
Category |
|
Type |
Proteins |
Specific against |
Human |
Host |
Human Cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Programmed cell death protein 1,PDCD1,PD-1,hPD-1,CD279,SLEB2,Hsle1 |
Similar products |
PD-1, PDCD1, CD279, SLEB2, hPD-1, Programmed cell death protein 1, Hsle1 |
Available |
|
Synonym |
Programmed cell death protein 1, PDCD1, PD-1, hPD-1, CD279, SLEB2, Hsle1 |
Storage |
according to manual |
Activity |
Immobilized Human PD-L1-Flag(Cat: PKSH032870) at 10ug/ml(100 ul/well) can bind Human PD-1-mFc. |
Protein Construction |
Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a mFc tag at the C-terminus. |
Sequence |
Leu25-Gln167 |
Fusion tag |
C-mFc |
Accession |
Q15116 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
42.0 kDa |
AP Mol Mass |
56 kDa |
Formulation |
Lyophilized from a 0.2 um filtered solution of 20mM PB; 150mM NaCl; pH7.2. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition; coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance; and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule; PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation; cytokine production; and cytolytic function. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.