Recombinant Human SERPINB1/PI2 Protein (Human Cells, His Tag)

Leukocyte elastase inhibitor, SERPINB1, Monocyte/neutrophil elastase inhibitor, M/NEI, Peptidase inhibitor 2, PI-2, PI2, EI, ELANH2, HEL-S-27, HEL57, LEI, MNEI,

Recombinant Human Serine Protease Inhibitor-clade B1 is produced by our Mammalian expression system and the target gene encoding Met1-Pro379 is expressed with a 6His tag at the C-terminus.

C-6His

This product is provided as lyophilized powder which is shipped with ice packs.

< 1.0 EU per ug as determined by the LAL method.

43.8 kDa

Lyophilized from a 0.2 um filtered solution of 20mM PB; 150mM NaCl; pH7.4.

SERPINB1 is a member of the serpin family and Ov-serpin subfamily. As protease inhibitors; serpins have an array of functions including regulating blood coagulation; fibrinolysis; the complement pathway; angiogenesis; inflammation; tumor suppression; extracellular matrix remodeling; and cell motility. SERPINB1 regulates the activity of the neutrophil proteases elastase; cathepsin G; proteinase-3; chymase; chymotrypsin; and kallikrein-3. Reactive bond 1 of SerpinB1 is specific for reaction with chymotrypsin-like protease such as cathepsin G; chymotrypsin or chymase. Reactive bond 2 of SerpinB1 is specific for reaction with elastase-like protease such as neutrophyl elastase; proteinase-3; pancreatic elastase or PSA. In addition; SERPINB1 also functions as a potent intracellular inhibitor of granzyme H.