Item no. |
ELS-PKSH032355-10ug |
Manufacturer |
Elabscience
|
Amount |
10ug |
Category |
|
Type |
Proteins |
Specific against |
Human |
Host |
Human Cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Dihydropteridine Reductase, HDHPR, Quinoid Dihydropteridine Reductase, QDPR, DHPR |
Similar products |
QDPR, DHPR, Quinoid Dihydropteridine Reductase, HDHPR, Dihydropteridine Reductase |
Available |
|
Synonym |
Dihydropteridine Reductase, HDHPR, Quinoid Dihydropteridine Reductase, QDPR, DHPR |
Storage |
according to manual |
Protein Construction |
Recombinant Human Dihydropteridine Reductase is produced by our Mammalian expression system and the target gene encoding Ala2-Phe244 is expressed with a 6His tag at the C-terminus. |
Sequence |
Ala2-Phe244 |
Fusion tag |
C-6His |
Accession |
P09417 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
26.8 kDa |
AP Mol Mass |
29 kDa |
Formulation |
Lyophilized from a 0.2 um filtered solution of 20mM TrisHCl, pH8.0. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family. QDPR exists as a homodimer. QDPR is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4 and tryptophan hydroxylases. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals in the brain called neurotransmitters, which transmit signals between nerve cells. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C) which is a rare autosomal recessive disorder and is lethal. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.