Item no. |
ELS-PKSH032272-50ug |
Manufacturer |
Elabscience
|
Amount |
50ug |
Category |
|
Type |
Proteins |
Specific against |
Human |
Host |
Human Cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Complement Factor B, C3/C5 Convertase, Glycine-Rich Beta Glycoprotein, GBG, PBF2, Properdin Factor B, CFB, BF, BFD |
Similar products |
CFB, BF, BFD, GBG, PBF2, Complement Factor B, C3/C5 Convertase, Glycine-Rich Beta Glycoprotein, Properdin Factor B |
Available |
|
Synonym |
Complement Factor B, C3/C5 Convertase, Glycine-Rich Beta Glycoprotein, GBG, PBF2, Properdin Factor B, CFB, BF, BFD |
Storage |
< -20CC |
Protein Construction |
Recombinant Human Complement Factor B is produced by our Mammalian expression system and the target gene encoding Thr26-Leu764 is expressed with a 6His tag at the C-terminus. |
Sequence |
Thr 26-Leu764 |
Fusion tag |
C-6His |
Accession |
P00751 |
Shipping |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20CC. |
Purity |
> 95 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Store at < -20CC, stable for 6 months. Please minimize freeze-thaw cycles. |
Mol Mass |
84.1 kDa |
AP Mol Mass |
90 kDa |
Formulation |
Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Complement Factor B (CFB) belongs to the peptidase S1 family of enzymes. It is expressed by hepatocytes and macrophages and localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. CFB which is a component of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.