Item no. |
ELS-PKSH032039-50ug |
Manufacturer |
Elabscience
|
Amount |
50ug |
Category |
|
Type |
Proteins |
Specific against |
Human |
Host |
Human Cells |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2 |
Similar products |
ACTR-IIA, ACVR2A, ACVR2, Activin Receptor Type IIA, ACTRIIA, Activin Receptor Type-2A |
Available |
|
Synonym |
Activin Receptor Type-2A, Activin Receptor Type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2 |
Storage |
according to manual |
Activity |
Immobilized Human INHBC-His(Cat: PKSH032587) at 0.8ug/ml(100 ul/well) can bind Human ACVR2A-Fc-6His. The ED50 of Human ACVR2A-Fc-6His is 6.73 ug/ml. |
Protein Construction |
Recombinant Human Activin Receptor Type-2A is produced by our Mammalian expression system and the target gene encoding Ala20-Pro134 is expressed with a Fc; 6His tag at the C-terminus. |
Sequence |
Ala20-Pro134 |
Fusion tag |
C-Fc-6His |
Accession |
P27037 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 95 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
41.2 kDa |
AP Mol Mass |
36 kDa |
Formulation |
Lyophilized from a 0.2 um filtered solution of 20mM PB; 150mM NaCl; pH7.4. |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.