Recombinant Human GAPDH Protein (His Tag)

G3PD, GAPD, HEL-S-162eP

A DNA sequence encoding the human GAPDH (P04406) (Met 1-Glu 335) was expressed, with a polyhistidine tag at the N-terminus.

N-His

This product is provided as lyophilized powder which is shipped with ice packs.

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38 kDa

Lyophilized from sterile 50mM Tris, 30% glycerol, pH 7.5

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimer's disease. Besides, deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinson's disease, binds to GAPDH and displays neuroprotective actions.