Item no. |
ELS-PKSH030708-100ug |
Manufacturer |
Elabscience
|
Amount |
100ug |
Category |
|
Type |
Proteins |
Specific against |
Human |
Host |
Baculovirus |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Signal Transducer and Activator of Transcription 6, IL-4 Stat, STAT6,IL-4-STAT,STAT6B,STAT6C |
Similar products |
STAT6, IL-4-STAT, STAT6B, STAT6C, IL-4 Stat, Signal Transducer and Activator of Transcription 6 |
Available |
|
Synonym |
Signal Transducer and Activator of Transcription 6, IL-4 Stat, STAT6, IL-4-STAT, STAT6B, STAT6C |
Storage |
according to manual |
Protein Construction |
A DNA sequence encoding the human STAT6 isoform 1 (P42226-1) (Met 1-Trp 847) was fused with a polyhistidine tag at the C-terminus. |
Sequence |
Met 1-Trp 847 |
Fusion tag |
C-His |
Accession |
P42226-1 |
Shipping |
This product is provided as lyophilized powder which is shipped with ice packs. |
Purity |
> 90 % as determined by reducing SDS-PAGE. |
Endotoxin |
< 1.0 EU per ug as determined by the LAL method. |
Stability and Storage |
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80CC. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months. |
Mol Mass |
95.5 kDa |
AP Mol Mass |
100 kDa |
Formulation |
Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 20% gly, 0.3mM DTT |
Reconstitution |
Please refer to the printed manual for detailed information. |
Background |
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-?B and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggest that the direct interaction between Stat6 and NF-?B may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-?B. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.