Item no. |
E-AB-40097-20 |
Manufacturer |
Elabscience
|
Amount |
20uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
CDKI, CDKN1A-interacting zinc finger protein 1, Cip1-interacting zinc finger protein, CIZ1, CIZ1, cyclin dependent inhibitor 1A, LSFR1, Melanoma differentiation-associated protein, NP94, Nuclear protein NP94, OPHN3, P21, Zinc finger protein 356, ZNF356 |
Similar products |
CIZ1, Melanoma differentiation-associated protein, OPHN3, P21, LSFR1, NP94, ZNF356, CDKN1A-interacting zinc finger protein 1, Cip1-interacting zinc finger protein, CDKI, cyclin dependent inhibitor 1A, Nuclear protein NP94, Zinc finger protein 356 |
Available |
|
Research Areas |
Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction |
Synonyms |
CDKI, CDKN1A-interacting zinc finger protein 1, Cip1-interacting zinc finger protein, CIZ1, CIZ1, cyclin dependent inhibitor 1A, LSFR1, Melanoma differentiation-associated protein, NP94, Nuclear protein NP94, OPHN3, P21, Zinc finger protein 356, ZNF356 |
Swissprot |
P38936 |
Background |
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). |
Concentration |
2 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant Human P21 protein |
Buffer |
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:500-1:1000 |
Conjugation |
Unconjugated |
Calculated MW |
18kDa |
Observed MW |
18kDa |
Gene ID |
1026 |
Santa Cruz # |
sc-471, sc-469, sc-397, sc-756 |
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