Item no. |
E-AB-40072-20 |
Manufacturer |
Elabscience
|
Amount |
20uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
IHC |
Specific against |
Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
CSIF, Cytokine synthesis inhibitory factor, GVHDS, IL 10, IL-10, IL10, IL10, IL10A, Interleukin 10, Interleukin-10, MGC126450, MGC126451, T-cell growth inhibitory factor, TGIF |
Similar products |
IL-10, IL10, Interleukin-10, Cytokine synthesis inhibitory factor, TGIF, Interleukin 10, IL 10, CSIF, IL10A, MGC126450, MGC126451, GVHDS, T-cell growth inhibitory factor |
Available |
|
Research Areas |
Cancer, Immunology |
Synonyms |
CSIF, Cytokine synthesis inhibitory factor, GVHDS, IL 10, IL-10, IL10, IL10, IL10A, Interleukin 10, Interleukin-10, MGC126450, MGC126451, T-cell growth inhibitory factor, TGIF |
Swissprot |
P18893 |
Background |
Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappaB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. |
Concentration |
2 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant Mouse Interleukin-10 protein |
Buffer |
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4. |
Purification Method |
Affinity purification |
Dilution |
IHC 1:50-1:100 |
Conjugation |
Unconjugated |
Santa Cruz # |
sc-7888 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.