Item no. |
E-AB-40059-60 |
Manufacturer |
Elabscience
|
Amount |
60uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
IHC |
Specific against |
Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
AHUS2, Antigen defined by monoclonal TRA 2 10, Antigen identified by monoclonal TRA 2 10, CD46, CD46 antigen, CD46 antigen complement regulatory protein, CD46 molecule, CD46 molecule complement regulatory protein, Complement membrane cofactor protein, MCP |
Similar products |
CD46, MCP, TLX, AHUS2, MGC26544, MIC10, TRA2.10, CD46 antigen, Membrane cofactor protein, Trophoblast leukocyte common antigen, CD46 molecule, CD46 molecule complement regulatory protein, Measles virus receptor, Trophoblast leucocyte common antigen, Trophoblast lymphocyte cross reactive antigen, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), Antigen defined by monoclonal TRA 2 10, Antigen identified by monoclonal TRA 2 10, CD46 antigen complement regulatory protein, Complement membrane cofactor protein |
Available |
|
Research Areas |
Cancer, Immunology |
Synonyms |
AHUS2, Antigen defined by monoclonal TRA 2 10, Antigen identified by monoclonal TRA 2 10, CD46, CD46 antigen, CD46 antigen complement regulatory protein, CD46 molecule, CD46 molecule complement regulatory protein, Complement membrane cofactor protein, MCP, MCP, Measles virus receptor, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), Membrane cofactor protein, MGC26544, MIC10, TLX, TRA2.10, Trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, Trophoblast lymphocyte cross reactive antigen |
Swissprot |
P15529 |
Background |
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization.Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. |
Concentration |
2 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant human Membrane cofactor protein |
Buffer |
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4. |
Purification Method |
Affinity purification |
Dilution |
IHC 1:50-1:100 |
Conjugation |
Unconjugated |
Santa Cruz # |
sc-7056, sc-9098 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.