ACY1 Polyclonal Antibody

ACY 1, ACY-1, Acy1, ACY1, ACY1D, ACYLASE, Acylase I, Aminoacylase-1, EC 3.5.1.14, epididymis secretory protein Li 5, HEL-S-5, N acyl L amino acid amidohydrolase, N-acyl-L-amino-acid amidohydrolase, OTTHUMP00000212459, OTTHUMP00000212462, OTTHUMP00000212463, OTTHUMP00000212464, OTTHUMP00000212465

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

WB 1:500 - 1:2000 IHC 1:50 - 1:200

37kDa/38kDa/42kDa/45kDa