Item no. |
E-AB-62859-60 |
Manufacturer |
Elabscience
|
Amount |
60uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
[Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, CMTX6, GS1-358P8.4, mitochondrial, PDK3, PDK3, Pyruvate dehydrogenase kinase isoenzyme 3, Pyruvate dehydrogenase kinase isoform 3, P |
Similar products |
PDK3, mitochondrial, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, Pyruvate dehydrogenase kinase isoform 3, CMTX6, GS1-358P8.4, [Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial, Pyruvate dehydrogenase kinase isoenzyme 3, Pyruvate dehydrogenase kinase isozyme 3, Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial |
Available |
|
Research Areas |
Cancer, Metabolism, Signal Transduction |
Synonyms |
[Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, CMTX6, GS1-358P8.4, mitochondrial, PDK3, PDK3, Pyruvate dehydrogenase kinase isoenzyme 3, Pyruvate dehydrogenase kinase isoform 3, Pyruvate dehydrogenase kinase isozyme 3, Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial |
Swissprot |
Q15120 |
Background |
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human PDK3 |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
Conjugation |
Unconjugated |
Calculated MW |
46kDa/48kDa |
Observed MW |
47kDa |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.