Item no. |
E-AB-53550-120 |
Manufacturer |
Elabscience
|
Amount |
120uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
0610041O14Rik, adapter protein ATH 55, Adapter protein ATH-55, Ath55, AV025587, Crn related protein kim1 , crn-related protein kim1, DKFZp762C1015, HCNP, HCNP protein, HCRN, KIAA1177, NTC90, PP3898, Pre-mRNA-splicing factor SYF1, Protein HCNP, RNA splicin |
Similar products |
HCNP, KIAA1177, SYF1, Pre-mRNA-splicing factor SYF1, Protein HCNP, XPA-binding protein 2, Xab2, HCRN, RNA splicing factor, DKFZp762C1015, NTC90, SYF1 homolog, crn-related protein kim1, 0610041O14Rik, adapter protein ATH 55, Adapter protein ATH-55, Ath55, AV025587, Crn related protein kim1, HCNP protein, PP3898, XPA binding protein 2, SYF1 pre mRNA splicing factor |
Available |
|
Research Areas |
Epigenetics and Nuclear Signaling |
Synonyms |
0610041O14Rik, adapter protein ATH 55, Adapter protein ATH-55, Ath55, AV025587, Crn related protein kim1 , crn-related protein kim1, DKFZp762C1015, HCNP, HCNP protein, HCRN, KIAA1177, NTC90, PP3898, Pre-mRNA-splicing factor SYF1, Protein HCNP, RNA splicing factor, SYF1, SYF1 homolog, SYF1 homolog, RNA splicing factor , SYF1 pre mRNA splicing factor, SYF1, Xab2, XPA binding protein 2, XPA-binding protein 2 |
Swissprot |
Q9HCS7 |
Background |
HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy. |
Concentration |
0.4 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Synthetic peptide of human XAB2 |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Calculated MW |
100 kDa |
Observed MW |
Refer to figures |
Gene Accession |
NP064581 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.