Item no. |
E-AB-52809-20 |
Manufacturer |
Elabscience
|
Amount |
20uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
IHC, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
0610011E17Rik, D4Bwg0593e, FLJ20312, MGC11707, MGC93828, MGC99541, OTTMUSP00000010360, OTTMUSP00000010366, pnrc2, PNRC2, Proline rich nuclear receptor coactivator 2, Proline-rich nuclear receptor coactivator 2, RP11-4M23.5, RP23-161N17.3 |
Similar products |
PNRC2, pnrc2, RP11-4M23.5, FLJ20312, MGC99541, Proline-rich nuclear receptor coactivator 2, 0610011E17Rik, D4Bwg0593e, MGC11707, MGC93828, OTTMUSP00000010360, OTTMUSP00000010366, Proline rich nuclear receptor coactivator 2, RP23-161N17.3 |
Available |
|
Research Areas |
Epigenetics and Nuclear Signaling |
Synonyms |
0610011E17Rik, D4Bwg0593e, FLJ20312, MGC11707, MGC93828, MGC99541, OTTMUSP00000010360, OTTMUSP00000010366, pnrc2, PNRC2, Proline rich nuclear receptor coactivator 2, Proline-rich nuclear receptor coactivator 2, RP11-4M23.5, RP23-161N17.3 |
Swissprot |
Q9NPJ4 |
Background |
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). |
Concentration |
0.84 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Fusion protein of human PNRC2 |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
IHC 1:50-1:300, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Gene Accession |
BC001959 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.