Item no. |
E-AB-14891-60 |
Manufacturer |
Elabscience
|
Amount |
60uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
cleavage and polyadenylation specific factor 4, 30kDa, Cleavage and polyadenylation specificity factor 30 kDa subunit, Cleavage and polyadenylation specificity factor subunit 4, cleavage polyadenylation specificity factor, 30kD, CPSF 30 kDa subunit, CPSF3 |
Similar products |
CPSF4, Cpsf4, CPSF30, NAR, NEB1, 30kD, 30kDa, Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, Neb-1, No arches homolog, cleavage and polyadenylation specific factor 4, cleavage polyadenylation specificity factor, no arches like zinc finger protein, NS1 effector domain binding protein 1, OTTHUMP00000206235, OTTHUMP00000206237, OTTHUMP00000206239 |
Available |
|
Research Areas |
Epigenetics and Nuclear Signaling, Microbiology |
Synonyms |
cleavage and polyadenylation specific factor 4, 30kDa, Cleavage and polyadenylation specificity factor 30 kDa subunit, Cleavage and polyadenylation specificity factor subunit 4, cleavage polyadenylation specificity factor, 30kD, CPSF 30 kDa subunit, CPSF30, Cpsf4, CPSF4, NAR, Neb-1, NEB1, No arches homolog, no arches like zinc finger protein, NS1 effector domain binding protein 1, NS1 effector domain-binding protein 1, OTTHUMP00000206235, OTTHUMP00000206237, OTTHUMP00000206239 |
Swissprot |
O95639 |
Background |
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. |
Concentration |
0.4 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human CPSF4 |
Buffer |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method |
Affinity purification |
Dilution |
WB 1:500-1:2000 |
Conjugation |
Unconjugated |
Calculated MW |
30kDa |
Gene Accession |
BC003101 |
Santa Cruz # |
sc-79418, sc-79417, sc-133480 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.