Alias |
AAG 11, AAG11, Aging associated gene 11, Down regulated in rhabdomyosarcoma LIM protein, Downregulated in rhabdomyosarcoma LIM protein, DRAL, FHL 2, FHL-2, Fhl2, FHL2 protein, FHL2, Four and a half LIM domain protein 2, Four and a half LIM domains 2, Four |
Synonyms |
AAG 11, AAG11, Aging associated gene 11, Down regulated in rhabdomyosarcoma LIM protein, Downregulated in rhabdomyosarcoma LIM protein, DRAL, FHL 2, FHL-2, Fhl2, FHL2 protein, FHL2, Four and a half LIM domain protein 2, Four and a half LIM domains 2, Four and a half LIM domains protein 2, KIAA0990, LIM domain protein DRAL, Skeletal muscle LIM protein 3, Skeletal muscle LIM-protein 3, SLIM 3, SLIM-3, SLIM3 |
Background |
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. |