UPF1 Polyclonal Antibody

ATP dependent helicase RENT1, ATP-dependent helicase RENT1, Delta helicase, FLJ43809, FLJ46894, HUPF 1, hUpf1, KIAA0221, Nonsense mRNA reducing factor 1, NORF 1, NORF1, pNORF 1, pNORF1, Regulator of nonsense transcripts 1, RENT 1, RENT1, RENT1, Smg 2, Smg 2 homolog nonsense mediated mRNA decay factor, UP Frameshift 1, Up frameshift mutation 1 homolog (S. cerevisiae), Up frameshift mutation 1 homolog, Up frameshift suppressor 1 homolog, Up-frameshift suppressor 1 homolog, UPF 1, UPF 1 regulator of nonsense transcripts homolog, upf1, UPF1 regulator of nonsense transcripts homolog, UPF1 RNA helicase and ATPase, Yeast Upf1p homolog

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

IHC 1:50 - 1:200

123kDa/124kDa