Item no. |
E-AB-63423-200 |
Manufacturer |
Elabscience
|
Amount |
200uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Frizzled 6 seven transmembrane spanning receptor, Frizzled drosophila homolog of 6, Frizzled family receptor 6, Frizzled homolog 6 (Drosophila), Frizzled homolog 6, Frizzled-6, Frizzled6, Fz 6, Fz-6, Fz6, FZD 6, Fzd6, FZD6, Hfz 6, hFz6, NDNC10 |
Similar products |
FZD6, Frizzled-6, Frizzled 6 seven transmembrane spanning receptor, Frizzled drosophila homolog of 6, Frizzled family receptor 6, Frizzled homolog 6, Frizzled6, Fz 6, Fz-6, Fz6, FZD 6, Fzd6, Hfz 6, hFz6, NDNC10, Frizzled homolog 6 (Drosophila) |
Available |
|
Research Areas |
Stem Cells |
Synonyms |
Frizzled 6 seven transmembrane spanning receptor, Frizzled drosophila homolog of 6, Frizzled family receptor 6, Frizzled homolog 6 (Drosophila), Frizzled homolog 6, Frizzled-6, Frizzled6, Fz 6, Fz-6, Fz6, FZD 6, Fzd6, FZD6, Hfz 6, hFz6, NDNC10 |
Swissprot |
O60353 |
Background |
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human FZD6 |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:1000 - 1:2000 |
Conjugation |
Unconjugated |
Calculated MW |
75kDa/79kDa |
Observed MW |
110kDa |
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