CRK Polyclonal Antibody

Adapter molecule crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, CRK, CRK isoform 2, CRK isoform II, CRK, CRKII, FLJ38130, OTTHUMP00000115366, OTTHUMP00000198330, p38, Proto oncogene C crk, Proto-oncogene C-crk, v crk avian sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog (avian)

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

WB 1:500 - 1:2000 IHC 1:50 - 1:200

22kDa/33kDa