Item no. |
E-AB-62054-60 |
Manufacturer |
Elabscience
|
Amount |
60uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Adapter molecule crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, CRK, CRK isoform 2, CRK isoform II, CRK, CRKII, FLJ38130, OTTHUMP00000115366, OTTHUMP00000198330, p38, Proto oncogene C crk, Proto-oncogene C-crk, v crk avian sarcoma virus CT10 onco |
Similar products |
CRK, p38, Adapter molecule crk, CRKII, CRK isoform 2, CRK isoform II, Proto oncogene C crk, v crk avian sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog, Proto-oncogene C-crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, FLJ38130, OTTHUMP00000115366, OTTHUMP00000198330, v crk sarcoma virus CT10 oncogene homolog (avian) |
Available |
|
Research Areas |
Cancer, Signal Transduction |
Synonyms |
Adapter molecule crk, Avian sarcoma virus CT10 (v crk) oncogene homolog, CRK, CRK isoform 2, CRK isoform II, CRK, CRKII, FLJ38130, OTTHUMP00000115366, OTTHUMP00000198330, p38, Proto oncogene C crk, Proto-oncogene C-crk, v crk avian sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog, v crk sarcoma virus CT10 oncogene homolog (avian) |
Swissprot |
P46108 |
Background |
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
Concentration |
1 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human CRK |
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method |
Affinity purification |
Dilution |
WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Conjugation |
Unconjugated |
Calculated MW |
22kDa/33kDa |
Observed MW |
37kDa |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.