ACTL6A Polyclonal Antibody

53 kDa BRG1 associated factor A, Actin like 6A, Actin like protein 6A, Actin related protein, Actin related protein Baf53a, actin-related protein 4, ACTL 6, ACTL 6A, ACTL6, ACTL6A, Arp4, ARPN BETA, ArpNbeta, BAF 53, BAF 53A, BAF complex 53 kDa subunit, BAF53, BRG1 associated factor 53A, BRG1 associated factor, BRG1/brm associated factor 53A, hArpN beta, INO80 complex subunit K, INO80K, MGC5382

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

WB 1:500 - 1:2000

43kDa/47kDa