Alias |
Anchorin CII, Annexin 5, Annexin A5, Annexin V, Annexin-5, ANX A5, ANX5, ANXA5, ANXA5, Calphobindin I, CBP-I, Endonexin II, ENX2, Lipocortin V, PAP I, PAP-I, Placental anticoagulant protein 4, Placental anticoagulant protein I, PLACENTAL PROTEIN 4, Pp4, T |
Synonyms |
Anchorin CII, Annexin 5, Annexin A5, Annexin V, Annexin-5, ANX A5, ANX5, ANXA5, ANXA5, Calphobindin I, CBP-I, Endonexin II, ENX2, Lipocortin V, PAP I, PAP-I, Placental anticoagulant protein 4, Placental anticoagulant protein I, PLACENTAL PROTEIN 4, Pp4, Thromboplastin inhibitor, VAC-alpha, Vascular anticoagulant-alpha |
Background |
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. |