Manufacturer |
Elabscience
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human, Mouse |
Isotype |
IgG |
Applications |
IHC, ELISA |
Amount |
200uL |
Host |
Rabbit |
Item no. |
E-AB-52936-200 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Alias |
KIAA0017, Pre mRNA splicing factor SF3b 130 kDa subunit, Pre-mRNA-splicing factor SF3b 130 kDa subunit, RSE1, SAP 130, SAP130, SF3b130, SF3B3, SF3B3_HUMAN, Spliceosome associated protein 130, Spliceosome-associated protein 130, Splicing factor 3b subunit |
Research Areas |
Epigenetics and Nuclear Signaling |
Synonyms |
KIAA0017, Pre mRNA splicing factor SF3b 130 kDa subunit, Pre-mRNA-splicing factor SF3b 130 kDa subunit, RSE1, SAP 130, SAP130, SF3b130, SF3B3, SF3B3_HUMAN, Spliceosome associated protein 130, Spliceosome-associated protein 130, Splicing factor 3b subunit 3 130kD, Splicing factor 3B subunit 3, STAF130 |
Swissprot |
Q15393 |
Background |
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. |
Concentration |
0.84 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Fusion protein of human SF3B3 |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
IHC 1:50-1:300, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Gene Accession |
BC000463 |
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