Item no. |
E-AB-19746-20 |
Manufacturer |
Elabscience
|
Amount |
20uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC, ELISA |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Actin binding protein, Clipin-C, CLIPINC, COR2B, CORO2B, Coronin actin binding protein 2B, Coronin, Coronin-2B, Coronin-like protein C, Protein FC96 |
Similar products |
CORO2B, CLIPINC, Coronin-2B, Coronin-like protein C, Protein FC96, Coronin, COR2B, Actin binding protein, Clipin-C, Coronin actin binding protein 2B |
Available |
|
Research Areas |
Signal transduction |
Synonyms |
Actin binding protein, Clipin-C, CLIPINC, COR2B, CORO2B, Coronin actin binding protein 2B, Coronin, Coronin-2B, Coronin-like protein C, Protein FC96 |
Swissprot |
Q9UQ03 |
Background |
Coronins are a family of WD repeat-containing, actin-binding proteins that localize to submembraneous areas and regulate cell motility and cytoskeletal rearrangement. Coronin 1A (CORO1A, CLIPINA, CLABP, TACO, p57) can form coiled coil-mediated homotrimeric complexes that influence early phagosome formation. PKC-dependent phosphorylation of Coronin 1B (CORO1B) at Serine 2 regulates leading edge dynamics and cell motility in fibroblasts through interactions with Arp2/3 complex. Coronin 1C (CORO1C, Coronin 3, HCRNN4) is abundant in differentiating Neuro-2a cells, PC-12 cells and primary oligodendrocytes, where it is thought to influence neuron morphogenesis and migration. Coronin 2A (CORO2A, CLIPINB, IR10, WDR2) is a component of the approximately 1.5-2 megadalton N-CoR (nuclear receptor corepressor) complex of 10-12 proteins, which recruits HDACs to generate repressive chromatin. Coronin 7 (CORO7, CRN7) localizes to the Golgi membrane and influences the organization of intracellular membrane compartments and vesicular trafficking. Coronin 2B (CORO2B, CLIPINC) and Coronin 6 (CORO6) are similar to other members of this family, since they possess a conserved basic N-terminal motif and 3-10 WD repeats clustered in one to two core domains. |
Concentration |
1.5 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Synthetic peptide of human CORO2B |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
WB 1:1000-1:5000, IHC 1:40-1:200, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Calculated MW |
55 kDa |
Observed MW |
Refer to figures |
Gene Accession |
NP006082 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.