Item no. |
E-AB-18829-20 |
Manufacturer |
Elabscience
|
Amount |
20uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
IHC, ELISA |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DNA polymerase eta, FLJ16395, FLJ21978, Polh, POLH, polymerase DNA directed eta, RAD30, RAD30 homolog A, RAD30A, Xeroderma pigmentosum variant type protein, XP V, XPV |
Similar products |
POLH, FLJ16395, FLJ21978, RAD30, RAD30A, XPV, DNA polymerase eta, RAD30 homolog A, Xeroderma pigmentosum variant type protein, Polh, polymerase DNA directed eta, XP V |
Available |
|
Research Areas |
Cancer, Epigenetics and Nuclear Signaling |
Synonyms |
DNA polymerase eta, FLJ16395, FLJ21978, Polh, POLH, polymerase DNA directed eta, RAD30, RAD30 homolog A, RAD30A, Xeroderma pigmentosum variant type protein, XP V, XPV |
Swissprot |
Q9Y253 |
Background |
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. |
Concentration |
1.08 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Fusion protein of human POLH |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
IHC 1:50-1:300, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Gene Accession |
BC015742 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.