Item no. |
E-AB-18574-120 |
Manufacturer |
Elabscience
|
Amount |
120uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, ELISA |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
C7, CO7, complement component 7, Complement component C7 |
Similar products |
C7, Complement component C7, complement component 7, CO7 |
Available |
|
Research Areas |
Cancer, Immunology |
Synonyms |
C7, CO7, complement component 7, Complement component C7 |
Swissprot |
P10643 |
Background |
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. C7 (Complement C7) is a Protein Coding gene. Diseases associated with C7 include C7 Deficiency and Immunodeficiency Due To A Late Component Of Complement Deficiency. Among its related pathways are Complement Pathway and Innate Immune System. An important paralog of this gene is C6. |
Concentration |
0.6 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Fusion protein of human C7 |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
WB 1:500-1:2000, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Calculated MW |
94 kDa |
Observed MW |
Refer to figures |
Gene Accession |
BC063851 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.